ABSTRACT
Adhesion of the SARS-CoV-2 virus spike protein was studied by vibrational spectroscopy using terahertz metamaterials. Specific features of metastructure absorption by histidine, albumin, and receptor-binding domain of spike protein films were investigated. An original method for quantitative estimation of the efficiency of virus adhesion on the surface of metamaterials has been proposed and experimentally tested. © 2022 IEEE.
ABSTRACT
Spectral properties of S and S1 spike proteins were studied using vibration spectroscopy methods. Also, vibration signatures of amino acids that make up the RGD, the part of S1 protein responsible for adhesion, were studied by Terahertz (THz) time-domain, Infrared (IR) and Raman spectroscopies in the low-frequency and in the fingerprint. THz metamaterials have been developed that increase the sensitivity of THz spectroscopy to the presence of both proteins. We have studied the spectra of amino acids, which play a role in the adhesion of proteins, on the metal surfaces of metamaterials, aluminum, and gold. Spectral differences were found between S and S1 proteins of SARS-CoV-2. The spectral differences between amino acids prepared in the form of thin films and in the form of bulk sample are discussed. © 2021 IEEE
ABSTRACT
Adhesion of the spike protein of the SARS-CoV-2 virus is studied by vibrational spectroscopy using terahertz metamaterials. The features of metastructure absorption upon the deposition of histidine, albumin, and the receptor-binding domain of the spike protein films are investigated. An original technique for quantitative assessment of the efficiency of virus adhesion on the metamaterial surfaces are proposed and experimentally tested.
ABSTRACT
Adhesion of the spike protein of the SARS-CoV-2 virus is studied by vibrational spectroscopy using terahertz metamaterials. The features of metastructure absorption upon the deposition of histidine, albumin, and the receptor-binding domain of the spike protein films are investigated. An original technique for quantitative assessment of the efficiency of virus adhesion on the metamaterial surfaces are proposed and experimentally tested. [ FROM AUTHOR] Copyright of Quantum Electronics is the property of IOP Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)